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استادیار گروه علوم و صنایع چوب و کاغذ دانشگاه تهران
3
university of tehran
Abstract
One application of hydrogels is to use them as dressings (wounds and burns). Biocompatibility and cytotoxicity are of particular significance for hydrogels used in the medical field. Cellulosic materials can load and relief drugs at temperatures or pH levels of the body as a result of contrary processes such as diffusion. The aim of this study was to investigate the mechanism of release of silver nitrate in nano-cellulose-based biodegradable hydrogel film for burn repair. To prepare a hydrogel in the form of film, cellulose nanofibers and hydroxyethyl cellulose were used with the weight ratio (3:1), and also, the citric acid was used as a crosslinker in different amounts of 10 and 20 wt% matrix. Later on, the loading silver nitrate as a disinfectant drug into selected hydrogels was performed. Drug release results illustrated that there was a direct relationship between absorption rate and drug concentration. In the initial times of the testing, 70 to 90% of the drug release was detected and then for 24 h, the drug was gradually released from the hydrogel. Investigation of modeling drug-releasing selected kinetic diffusion as the dominant mechanism in drug delivery. MTT non-toxicity test displayed high efficacy of nanocellulose cationization and confirmed the non-toxicity of biocompatible hydrogels. It can be concluded that biodegradable nanocellulose based hydrogel containing silver nitrate can be used as an appropriate and relevant product for burn repair.
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Jonoobi, M., moradpour, P., & Tofangchi Kalle basti, A. A. (2020). Investigation of releasing mechanism of silver nitrate in the nanocellulose based hydrogel pad for burn healing. Iranian Journal of Wood and Paper Industries, 11(2), 333-344.
MLA
Mehdi Jonoobi; payam moradpour; ali akbar Tofangchi Kalle basti. "Investigation of releasing mechanism of silver nitrate in the nanocellulose based hydrogel pad for burn healing". Iranian Journal of Wood and Paper Industries, 11, 2, 2020, 333-344.
HARVARD
Jonoobi, M., moradpour, P., Tofangchi Kalle basti, A. A. (2020). 'Investigation of releasing mechanism of silver nitrate in the nanocellulose based hydrogel pad for burn healing', Iranian Journal of Wood and Paper Industries, 11(2), pp. 333-344.
VANCOUVER
Jonoobi, M., moradpour, P., Tofangchi Kalle basti, A. A. Investigation of releasing mechanism of silver nitrate in the nanocellulose based hydrogel pad for burn healing. Iranian Journal of Wood and Paper Industries, 2020; 11(2): 333-344.
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