یکی از کاربردهای هیدروژلها، استفاده از آن بهعنوان پانسمان (زخم و سوختگی) میباشد. زیستسازگاری و عدم سمیت سلولی برای هیدروژلهای مورداستفاده در زمینه پزشکی اهمیت ویژه‌ای دارد. مواد سلولزی میتوانند داروها را بارگذاری کرده و در شرایط دمایی و یا pH سطح بدن در اثر فرآیندهای مختلف مانند انتشار، داروها را آزاد کنند. هدف از این مطالعه بررسی مکانیسم رهایش نیترات نقره در فیلم هیدروژل زیست‌تخریب‌پذیر بر پایه نانوسلولز جهت ترمیم سوختگی بود. جهت تهیه فیلم هیدروژل، از نانوالیاف سلولزی و هیدروکسی اتیل سلولز با نسبت وزنی (3 به 1) و همچنین از سیتریک اسید بهعنوان اتصال‌دهنده عرضی با مقادیر 10 و 20 درصد وزنی نسبت به بستر استفاده شد. سپس بارگذاری نیترات نقره بهعنوان یک داروی ضدعفونی‌کننده به هیدروژلهای تهیه‌شده انجام شد. نتایج رهایش دارو نشان داد که رابطه خطی بین میزان جذب و غلظت داروی مربوطه وجود دارد. در ساعات اولیه آزمایش، 70 تا 90 درصد از رهایش دارو مشاهده شد و سپس تا 24 ساعت، دارو به‌آرامی از هیدروژل آزاد گردید. مدل‌سازی رهایش دارو، انتشار فیک را بهعنوان مکانیسم غالب در تحویل دارو انتخاب کرد. آزمون عدم سمیت MTT، اثربخشی بالای کاتیونیزاسیون نانوسلولز را نشان داد و مؤید عدم سمیت هیدروژلهای بر پایه مواد زیست سازگار بود. میتوان نتیجهگیری کرد که هیدروژل زیست‌تخریب‌پذیر بر پایه نانوسلولزکه حاوی نیترات نقره است، بهعنوان یک محصول کاملاً مناسب و کاربردی جهت ترمیم سوختگی قابل‌استفاده میباشد.
Gibs, I. and Janik, H. 2010. Review: synthetic polymer hydrogels for biomedical applications. Chemistry and Chemical Technology. 4:4.297-304.
Sood, A., Granick, M.S. and Tomaselli, N.L. 2014. Wound dressings and comparative effectiveness data. Advances in wound care. 3:8.511-529.
Morkhande, V.K., Pentewar, R.S., Gapat, S.V., Sayyad, S.R., Amol, B.D., Sachin, B. and Sandip K. 2016. A Review on Hydrogel. Pharmecy Research 6: 4678-4689.
Ganji, F. and Vasheghani-Farahani E. 2009. Hydrogels in Controlled Drug Delivery Sys tems. Iran Polymer Journal. 18: 63-88.
Winter, G.D. 1962. Formation of the scab and the rate of epithelization of superficial wounds in the skin of the young domestic pig, Nature. 193:4812. 293-294.
Naves, L.B., Almedia, L. 2015. Wound Healing Dressing and Some Composites Such as Zeolite, TiO2, Chitosan and PLGA: A Review. International Journal of Materials and Metallurgical Engineering. 9:3. 242-246.
Dhivyaa, S., Padmab, V.V. and Santhinia, E. 2015. Wound dressing- a review. BioMedicine. 5:4.24-28.
Hunt, T.K., Hopf, H. and Hussain, Z. 2000. Physiology of wound healing. Advances in skin & wound care. 13: 6-11.
Rivera, A.E. and Spencer, J.M. 2007. Clinical aspects of full-thickness wound healing. Clinics in dermatology. 25:1. 39-48.
Strecker-McGraw, MK., Jones, T.R. and Baer, D.G. 2007. Soft tissue wounds and principles of healing. Emergency Medicine Clinics North American. 25:1. 1-22.
Debra, J.B. and Cheri, O. 1998. Wound healing: Technological innovations and market overview. Technology Catalysts International Corporation, 2: 1-185.
Kamoun, E.A., Kenawy, E.S. and Chen, X. 2017. A review on polymeric hydrogel membranes for wound dressing applications: PVA-based hydrogel dressings. Journal of Advanced Research. 8: 217-233.
Morgan, DA. 1999. Wound management products in the drug tariff. Pharmaceutical journal. 263: 820-825.
Liu, J., Willf?r, S. and Xu, C. 2015. A review of bioactive plant polysaccharides: Biological activities, functionalization, and biomedical applications. Bioact Carbohydr Diet Fibre, 5(1):31-61.
Zhao, W., Jin, X., Cong, Y., Liu, Y. and Fu. J. 2013. Degradable natural polymer hydrogels for articular cartilage tissue engineering. Jornal of Chemical Technology and Biotechnology. 88:3.327-39.
Robinson, J.R. and Lee, V.H.L. 1987. Controlled drug delivery: Fundamentals and applications. 2nd edition. New York: Marcel Dekker.
Lee, J.W. and Park R.J.H. 2000. Bioadhesive-based dosage forms: The next generation. Journal of Pharmaceutical Sciences. 89:7.850-866.
Lu, T., Li, Q., Chen, W. and Yu, H. 2014. Composite aerogels based on dialdehyde nanocellulose and collagen for potential applications as wound dressing and tissue engineering scaffold, Composites Science and Technology. 94: 132-138.
Martson, M., Viljanto, J., Hurme, T., Laippala, P., and Saukko, P. 1999. Is cellulose sponge degradable or stable as implantation material? An in vivo subcutaneous study in the rat, Biomaterials. 20:21.1989-1995.
Babu, R., O'Connor, K. and Seeram, R. 2013. Current progress on bio-based polymers and their future trends. Progress in Biomaterials. 2: 1. 8.
Sannino, A., Demitri, Ch., and Madaghiele, M. 2009. Biodegradable cellulose-based hydrogels: design and applications. Materials. 2: 353-373.
Sell, S.A., Wolfe, P.S., Garg, K., McCool, J.M., Rodriguez, I.A., and Bowlin, G. L. 2010. The use of natural polymers in tissue engineering: a focus on electrospun extracellular matrix analogues. Polymers. 2: 522-553.
Kolakovic, R., Peltonen, L., Laukkanen, A., Hirvonen, J. and Laaksonen, T. 2012. Nanofibrillar cellulose films for controlled drug delivery. European Journal of Pharmaceutics and Biopharmaceutics, 82(2):308-3015.
Mihranyan, A. and Andersson, S.B. 2004. Sorption of nicotine to cellulose powders. European Journal Pharmaceutical Sciences, 22(4):279-86.
Trovatti, E., Silva, N.H., Duarte, I.F., Rosado, C.F., Almeida, I.F. and Costa, P. 2011. Biocellulose membranes as supports for dermal release of lidocaine. Biomacromolecules, 12(11):4162-8.
Dash, R. and Ragauskas, A.J. 2012. Synthesis of a novel cellulose nanowhisker-based drug delivery system. RSC Adv, 2(8):3403-3409.
Lin, N. and Dufresne, A. 2013. Supramolecular hydrogels from in situ host-guest inclusion between chemically modified cellulose nanocrystals and cyclodextrin. Biomacromolecules, 14(3):871-880.
Shetye, S.P., Godbole, A., Bhilegaokar, Sh., and Gajare, P. 2015. Hydrogels: Introduction, Preparation, Characterization and Applications. International Journal of Research Methodology. 1:47-71.
Motie, N., Jonoobi, M., Faezipour M.M., Mahboobian, M.M. and Borzacchiello A. 2019. Nanocellulose based biohydrogel preparation and characterization of some Properties. Iranian Journal of Wood and Paper Industries. 9:4.497-509.
Trovattia, E., Freire, C. S.R., Pinto, P. C., Almeida, I. F., Costa, P., Silvestre, A. J.D., Neto, C. P., and Rosadob, C. 2012. Bacterial cellulose membranes applied in topical and transdermal delivery of lidocaine hydrochloride and ibuprofen: In vitro diffusion studies. International Journal of Pharmaceutics. 435: 83- 87.
Qi, X., Li, J., Wei, W., Zuo, G., Su, T., Pan, X., Zhang, J., and Dong, W. 2017. Cationic Salecan-based hydrogels for release of 5- fluorouracil, RSC Advances. 7: 14337-14347.
Ritger, Ph.L. and Peppas, N.A. 1987. A simple equation for description of solute release II. Fickian and Anomalous release from swellable devices. Journal of Controlled Release. 5: 37-42.
Behnia, N. and Pirouzfar, V. 2018. Effect of operating pressure and pyrolysis conditions on the performance of carbon membranes for CO2/CH4 and O2/N2 separation derived from polybenzimidazole/Matrimid and UIP-S precursor blends. Polymer Bulletin. 75: 10. 4341-4358.
Rodriguez, R., Alvarez-Lorenzo, C. and Concheiro, A. 2003. Cationic cellulose hydrogels: kinetics of the cross-linking process and characterization as pH-/ ion-sensitive drug delivery systems. Journal of Controlled Release. 86: 253-265.
Wilhelms, T.A., Schulze, D., Alupeil, C., I, Rohrer, C., Abel, M., Wiegand, C. and Hipler, U.C. 2007. Release of polyhexamethylene biguanide hydrochloride (PHMB) from a hydroballanced cellulose wound dressing with PHMB. 17th Conference of the European Wound Management Association Glasgow/UK.
Korsmeyer, R.W., Gurny, R., Doelker, E., Buri, P. and Peppas, N.A. 1983. Mechanisms of solute release from porous hydrophilic polymers. International Journal of Pharmaceutics. 15: 25-35.
Huang, L., Chen, X., Nguyen, T.X., Tang, H., Zhang, L. and Yang, G. 2013. Nanocellulose 3D-networks as controlled-release drug carriers. Journal of Materials Chemistry B1. 23: 2976- 2984.
Amin, M.C.I.M., Ahmad, N., Halib, N. and Ahmad, I. 2012. Synthesis and characterization of thermo- and pH-responsive bacterial cellulose/acrylic acid hydrogels for drug delivery. Carbohydrate Polymers. 88:465-473.
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